Holding hands is one of the most basic, platonic, and visible ways to express affection, friendship, or love. Because holding hands can be platonic, it can be shown in any work, between any people. If someone offers a hand to hold, and the person it was offered to rejects it, odds are something is wrong with at least one of them.
When holding hands is shown between people who can reasonably be eventually romantically linked, it is often either symbolic of the link or a prelude to it, depending on the rating of the work. Even if it isn't, it likely will be in the Fan Fic due to shipping.
Holding hands can be a gesture of solidarity. When a group of people join hands in a circle, that can mean friendship, dancing, or (in some works) a magic ritual.
- This trope is prominent in WALL•E. One of the more iconic bits is WALL•E holding his own hand out of loneliness. Notably, while WALL•E's First Kiss with EVE comes about halfway through the film, the hand holding doesn't happen until the finale.
- The scene in Tarzan where Tarzan and Jane press their palms up towards each other.
- Toy Story 3: In the climactic scene, the toys are trapped in the incinerator and facing certain death. Instead of panicking, they join hands and choose to meet their fate together.